Jakarta, INTI – A major challenge in cancer immunotherapy is that cancer cells tend to disguise themselves, making it difficult for immune cells to recognize and attack them. To address this issue, a team of researchers from the Chinese Academy of Sciences (CAS) has introduced a nanotechnology innovation capable of accurately tagging cancer cells. In the latest study led by Han Shuo from the Center of Excellence in Molecular Cell Science, scientists developed engineered “nanozymes” that can respond to near-infrared light or ultrasonography. This nano-tagging tool, presented in recent research publications, represents a breakthrough to enhance the effectiveness of cancer immunotherapy and provide solutions for patients who have been challenging to treat.
Nano Technology for Cancer Cell Identification
The nanozyme functions as a “nano-tagging robot” capable of carrying specific antibodies or ligands, recognizing cancer cells, and binding to their surfaces via blood circulation. By receiving instructions through near-infrared light or ultrasonography, the nanozyme can clearly mark cancer cells, allowing immune cells to identify and target them more effectively.
Immune System Activation and BiTE Molecules
In addition to tagging cancer cells, researchers also injected specially designed BiTE molecules into experimental mice. These molecules not only identify cancer targets but also activate T cells to assist in fighting the cancer. Han Shuo explained that this tagging system can stimulate the overall immune response and form long-term immune memory, functioning like a “tumor vaccine” delivered inside the body.
Experimental Results and Future Potential
The study has shown significant therapeutic effects in mouse tumor models and clinical tumor samples in vitro. According to Han, this innovation paves the way for the development of the next generation of immunotherapy that is smarter, more efficient, and highly targeted, potentially improving cancer treatment success in the future.
Conclusion
The nano-tagging tool developed by CAS demonstrates that combining nanotechnology with immunotherapy can be a revolutionary solution for cancer. With its ability to accurately mark cancer cells while simultaneously activating the immune system, this innovation marks a significant step forward in creating more effective and safer immunotherapy.
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Author: Nd